Afrezza Teaching

All Insulin is Not Created Equally. Do Not Compare, Do Not Judge.

Do Learn.

Step #1 – Pure Effect Challenge

1. Wake with blood glucose near 200mg/dL and do not have any insulin on board other than basal insulin
2. Take a Blue cartridge, do not eat, do not exercise, and wait 90 minutes
3. Assess blood glucose drop
4. Repeat 2–3x
5. Can conduct Pure Effect Challenge at other times to see if sensitivity changes throughout the day

Step #2 – Meal Dose Effect Challenge

1. Choose one meal with known amount of carbohydrate (ideally 30–50g)
2. Check blood glucose prior to meal and take Blue cartridge
3. Check blood glucose 90 min post meal
4. Repeat 2–3x

How to Assess

1. If blood glucose does not return to target (80–130mg/dL), increase to Green cartridge and repeat test 2–3x
2. If have low blood glucose within 30 min of meal, then push dose to 20 min after meal
3. If have low blood glucose within 45–90 min of meal, then dose too strong/need larger carb intake

Important to Keep in Mind

• Action of inhaled dose: 12 min to 1st measurable effect, 35min to peak effect, 90min return to baseline
• Full dose is in pulmonary system within 1 second of inhalation. May have cough or tickle in throat. If so, drink water.  
• When to safely take correction dose—no sooner than 90 min from last inhaled dose
• Avoid combining with injected dose at all times, as it complicates evaluation of inhaled dose
• Storage: 
  • Unopened blister pack at room temp good for 10 days
  • Opened blister pack at room temp good for 3 days 
  • Keep in refrigerator otherwise
  • Must be out of refrigerator for 10 min prior to use
• Do not use inhaler for more than 15 days
• How to properly use inhaler and dispose of cartridges (view online tutorial at www.afrezza.com)