Benefits
- Reduces A1c
- Improves insulin sensitivity
- May preserve or improve β-cell function
- May slightly lower triglycerides and increase HDL
- May slightly lower blood pressure
- May reduce liver fat content
Safety / Adverse Reactions
- Weight gain
- Fluid retention, increased risk for causing/worsening heart failure
- Increased fracture risk in postmenopausal women
- Possible association with bladder cancer
Monitoring
- Measure liver tests before starting and if symptoms of liver failure arise