Thiazolidinediones

Benefits

• Reduces A1c
• Improves insulin sensitivity
• May preserve or improve β-cell function 
• May slightly lower triglycerides and increase HDL 
• May slightly lower blood pressure
• May reduce liver fat content

Safety / Adverse Reactions

• Weight gain 
• Fluid retention, increased risk for causing/worsening heart failure 
• Increased fracture risk in postmenopausal women
• Possible association with bladder cancer

Monitoring

• Measure liver tests before starting and if symptoms of liver failure arise